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ANXIETY AFTER STROKE: A SYSTEMATIC REVIEW AND META-ANALYSIS

Journal article
Authors Lena Rafsten
Anna Danielsson
Katharina S Sunnerhagen
Published in Journal of Rehabilitation Medicine
Volume 50
Issue 9
Pages 769-778
ISSN 1650-1977
Publication year 2018
Published at Institute of Neuroscience and Physiology, Department of Health and Rehabilitation
Pages 769-778
Language en
Links dx.doi.org/10.2340/16501977-2384
Keywords anxiety, epidemiology, stroke, review, acute ischemic-stroke, quality-of-life, depression rating-scale, hospital anxiety, generalized anxiety, screening instruments, poststroke, depression, natural-history, mood symptoms, global burden, Rehabilitation, Sport Sciences
Subject categories Neurosciences

Abstract

Objective: To update the evidence surrounding the presence of anxiety after stroke. Data sources: A search was conducted in EMBASE, MEDLINE, PsycINFO, Cochrane Library, AMED and CINAHL in May 2015 and repeated in April 2017. Study selection: Clinical diagnosis of stroke and assessed for anxiety symptoms on a rating scale in the first year after stroke. Data extraction: One reviewer screened and identified studies against the inclusion criteria. A second reviewer conducted a random check of approximately 10% of titles and abstracts. Two authors independently performed the final full-text review. Data synthesis: Overall pooled prevalence of anxiety disorders was 29.3% ((95% confidence interval 24.8-33.8%), (I-2 = 97%, p < 0.00001)) during the first year. Frequency 0-2 weeks post-stroke was 36.7%, 2 weeks to 3 months 24.1%, and 3-12 months 23.8%. There was a statistically high heterogeneity in this estimate (I-2 = 97%, p < 0.00001). Conclusion: Anxiety is common during the first year post-stroke. Since anxiety significantly influences quality of life and is a predictor for depression, it may be worth considering further routine screening post-stroke.

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