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Early self-reported pain in juvenile idiopathic arthritis (JIA) is related to long-term outcomes. Results from the Nordic JIA cohort study.

Journal article
Authors Ellen Dalen Arnstad
Veronika Rypdal
Suvi Peltoniemi
Troels Herlin
Lillemor Berntson
Anders Fasth
Susan Nielsen
Mia Glerup
Maria Ekelund
Marek Zak
Kristiina Aalto
Ellen Nordal
Pål Richard Romundstad
Marite Rygg
Published in Arthritis care & research
Volume 71
Issue 7
Pages 961-969
ISSN 2151-4658
Publication year 2019
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages 961-969
Language en
Links dx.doi.org/10.1002/acr.23715
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Pediatrics, Rheumatology and Autoimmunity

Abstract

To study self-reported pain early in the disease course of juvenile idiopathic arthritis (JIA) as predictor of long-term disease outcomes.Consecutive cases of JIA with disease onset 1997-2000 from defined geographical areas of Norway, Sweden, Finland and Denmark were prospectively enrolled in this population-based cohort study. Self-reported, disease-related pain was measured on a 10 cm visual analogue scale (VAS pain). Inclusion criteria were a baseline visit with pain score six months after disease onset, followed by an eight-year study visit. Remission was defined according to Wallace preliminary criteria. Functional disability was measured by Childhood Health Assessment Questionnaire (CHAQ) and Child Health Questionnaire (CHQ-PF50) if age <18 and Health Assessment Questionnaire (HAQ) if age ≥18 years. Damage was scored using the Juvenile Arthritis Damage Index (JADI).The final study cohort consisted of 243 participants, and 120 (49%) had oligoarticular onset. At baseline 76% reported VAS pain >0 compared to 57% at eight-year. Half of those who reported baseline pain also reported pain at eight-year, but at a lower intensity. Compared to no pain, higher pain intensity at baseline predicted more pain at eight-year, more functional disability, more damage and less remission off medication. Baseline pain predicted more use of DMARDs/biologics during the disease course. Participants with oligoarticular JIA reporting pain at baseline were more likely to develop extended oligoarticular or other unfavorable JIA categories.Early self-reported, disease-related pain among children and adolescents with JIA is common and seems to predict persistent pain and unfavorable long-term disease outcomes. This article is protected by copyright. All rights reserved.

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