To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Fibrinogen concentrations… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Fibrinogen concentrations predict long-term cognitive outcome in young ischemic stroke patients

Journal article
Authors Annie Pedersen
Tara M Stanne
Petra Redfors
Jo Inge Viken
Hans Samuelsson
Staffan Nilsson
Katarina Jood
Christina Jern
Published in Research and Practice in Thrombosis and Haemostasis
Volume 2
Issue 2
Pages 339-346
ISSN 2475-0379
Publication year 2018
Published at Department of Mathematical Sciences
Institute of Neuroscience and Physiology
Institute of Biomedicine
Department of Psychology
Pages 339-346
Language en
Keywords cardiovascular diseases, cognition, hemostasis, prognosis, stroke, c-reactive protein, plasminogen-activator, sahlgrenska-academy, impairment, association, markers, risk, frequency, institute, dementia
Subject categories Cardiac and Cardiovascular Systems


Background: Cognitive impairment is frequent after stroke, and young patients may live with this consequence for a long time. Predictors of cognitive outcomes after stroke represent a current gap of knowledge. Objectives: To investigate levels of three hemostatic biomarkers as predictors of long-term cognitive function after stroke. Methods: This longitudinal study included consecutively recruited patients with ischemic stroke at 18-69 years (n = 268). Blood was collected 3 months after index stroke and analyzed for plasma concentrations of fibrinogen, von Willebrand factor (VWF) and tissue-type plasminogen activator (t-PA) antigen. Cognitive function 7 years after index stroke was assessed by the Barrow Neurological Institute Screen for Higher Cerebral Functions (BNIS). Participants with stroke <50 years of age were also examined by the Trail Making Test A and B (n = 41). Associations between biomarker concentrations and cognitive scales were assessed in the whole group and in participants with stroke <50 years of age. Results: The hemostatic biomarkers fibrinogen, VWF and t-PA, were all correlated to total BNIS score, but these associations did not withstand adjustment for confounding factors in the whole group. However, in patients <50 years, we found an independent association between fibrinogen concentrations and total BNIS score (beta(std) = -.27, 95% confidence interval [CI], -0.47 to -0.07) and to performance on the Trail Making Test A (beta(std) = 31, 95% CI, 0.03-0.58). No such association was seen for the Trail Making Test B. Conclusion: High convalescent fibrinogen concentrations were associated with worse long-term cognitive outcomes in ischemic stroke <50 years of age. We propose further investigations of fibrinogen in relation to cognitive function in stroke in the young.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?