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Projection-based respiratory-resolved left ventricular volume measurements in patients using free-breathing double golden-angle 3D radial acquisition.

Journal article
Authors Karen Holst
Alexander Fyrdahl
Kenneth Caidahl
Martin Ugander
Andreas Sigfridsson
Published in Magma
Volume 32
Issue 3
Pages 331–341
ISSN 1352-8661
Publication year 2019
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 331–341
Language en
Keywords Cardiac imaging; Golden-angle; Radial; Respiratory resolved; Self-gating; Three-dimensional
Subject categories Cardiac and Cardiovascular Systems, Clinical Laboratory Medicine, Medical Image Processing


To refine a new technique to measure respiratory-resolved left ventricular end-diastolic volume (LVEDV) in mid-inspiration and mid-expiration using a respiratory self-gating technique and demonstrate clinical feasibility in patients.Ten consecutive patients were imaged at 1.5 T during 10 min of free breathing using a 3D golden-angle radial trajectory. Two respiratory self-gating signals were extracted and compared: from the k-space center of all acquired spokes, and from a superior-inferior projection spoke repeated every 64 ms. Data were binned into end-diastole and two respiratory phases of 15% respiratory cycle duration in mid-inspiration and mid-expiration. LVED volume and septal-lateral diameter were measured from manual segmentation of the endocardial border.Respiratory-induced variation in LVED size expressed as mid-inspiration relative to mid-expiration was, for volume, 1 ± 8% with k-space-based self-gating and 8 ± 2% with projection-based self-gating (P = 0.04), and for septal-lateral diameter, 2 ± 2% with k-space-based self-gating and 10 ± 1% with projection-based self-gating (P = 0.002).Measuring respiratory variation in LVED size was possible in clinical patients with projection-based respiratory self-gating, and the measured respiratory variation was consistent with previous studies on healthy volunteers. Projection-based self-gating detected a higher variation in LVED volume and diameter during respiration, compared to k-space-based self-gating.

Page Manager: Webmaster|Last update: 9/11/2012

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