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CMY-1/MOX-family AmpC β-lactamases MOX-1, MOX-2 and MOX-9 were mobilized independently from three Aeromonas species.

Journal article
Authors Stefan Ebmeyer
Erik Kristiansson
D. G. Joakim Larsson
Published in The Journal of antimicrobial chemotherapy
Volume 74
Issue 5
Pages 1202–1206
ISSN 1460-2091
Publication year 2019
Published at Department of Mathematical Sciences
Centre for antibiotic resistance research, CARe
Institute of Biomedicine, Department of Infectious Medicine
Pages 1202–1206
Language en
Links dx.doi.org/10.1093/jac/dkz025
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Microbiology in the medical area, Bioinformatics (Computational Biology), Bioinformatics and Systems Biology, Genetics

Abstract

To investigate the origin of CMY-1/MOX-family β-lactamases.Publicly available genome assemblies were screened for CMY-1/MOX genes. The loci of CMY-1/MOX genes were compared with respect to synteny and nucleotide identity, and subjected to phylogenetic analysis.The chromosomal ampC genes of several Aeromonas species were highly similar to known mobile CMY-1/MOX variants. Annotation and sequence comparison revealed nucleotide identities >98% and conserved syntenies between MOX-1-, MOX-2- and MOX-9-associated mobile sequences and the chromosomal Aeromonas sanarellii, Aeromonas caviae and Aeromonas media ampC loci. Furthermore, the phylogenetic analysis showed that MOX-1, MOX-2 and MOX-9 formed three distinct monophyletic groups with the chromosomal ampC genes of A. sanarellii, A. caviae and A. media, respectively.Our findings show that three CMY-1/MOX-family β-lactamases were mobilized independently from three Aeromonas species and hence shine new light on the evolution and emergence of mobile antibiotic resistance genes.

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