To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

A randomized, controlled,… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

A randomized, controlled, clinical study on a new titanium oxide abutment surface for improved healing and soft tissue health.

Journal article
Authors Jan Hall
Jessica Neilands
Julia R Davies
Annika Ekestubbe
Bertil Friberg
Published in Clinical implant dentistry and related research
Volume 21
Issue S.1
Pages 55-68
ISSN 1708-8208
Publication year 2019
Published at Institute of Odontology
Pages 55-68
Language en
Subject categories Radiological research


A newly developed, anodized titanium oxide surface containing anatase has been reported to have antimicrobial properties that could reduce bacterial adherence to abutments.To investigate if abutments with the anodized surface improve healing and soft tissue health in a randomized controlled study.Test abutments with a nanostructured anodized surface were compared with control machined titanium abutments. In total, 35 subjects each received a pair of test and control abutments. The primary endpoint was reduction of biofilm formation at test abutments at the 6-week follow-up. Secondary endpoints included several soft tissue assessments. qPCR for gene markers was used to indirectly evaluate healing and soft tissue health.No significant differences in biofilm formation were observed between test and control abutments, but soft tissue bleeding upon abutment removal was significantly lower for test abutments compared with control abutments (P = 0.006) at 6 weeks. Keratinized mucosa height was significantly greater at test abutments compared with control abutments at the 6-week, 6-month, and 2-year follow-ups. Significant gene expression differences indicated differences in healing and tissue remodeling.Abutments with an anodized and nanostructured surface compared with a conventional, machined titanium surface had no significant effect on bacterial colonization and proteolytic activity but were associated with better soft tissue outcomes such as a lower bleeding index at abutment removal and consistently greater height of keratinized mucosa throughout the 2-year follow-up, suggesting improved surface-dependent peri-implant healing and soft tissue health.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?