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Health-Related Quality of Life in Turner Syndrome and the Influence of Growth Hormone Therapy: a 20-Year Follow-up.

Journal article
Authors Emily Krantz
Kerstin Landin-Wilhelmsen
Penelope Trimpou
Inger Bryman
Ulla Wide
Published in The Journal of clinical endocrinology and metabolism
Volume 104
Issue 11
Pages 5073–5083
ISSN 1945-7197
Publication year 2019
Published at Institute of Odontology, Section 1
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 5073–5083
Language en
Links dx.doi.org/10.1210/jc.2019-00340
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Endocrinology, Obstetrics and gynaecology

Abstract

The factors that affect the Health-Related Quality of Life (HRQoL) of women with Turner Syndrome (TS) are controversial.The aim was to describe the HRQoL of women with TS with a focus on how given growth hormone (GH) treatment and comorbidity influence HRQoL in adulthood, and to compare HRQoL of women with TS with that of women in the general population.Longitudinal cohort study, up to 20 years.The Turner Center at the Section for Endocrinology and Department of Reproductive Medicine at Sahlgrenska University Hospital, Gothenburg, Sweden.Women with TS, n=200, age range 16-78 yrs, were included consecutively and monitored every fifth year between 1995 and 2018. Women from the WHO-MONICA project were used as reference populations.HRQoL was measured using the Psychological General Well-Being index (PGWB) and the Nottingham Health Profile (NHP). Associations with somatic variables were assessed using longitudinal linear regression models.HRQoL was not associated with GH treatment in TS in spite of a mean 5.7 cm taller height. HRQoL was only associated with height per se in one of 13 subscales (p<0.01). HRQoL was negatively affected by higher age, higher age at diagnosis, and hearing impairment in TS. Women with TS reported a similar HRQoL to the reference population.No association between previous GH treatment and HRQoL was found during the up to 20-yrs of follow-up in women with TS. HRQoL of women with TS and the reference population was similar.

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