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Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men

Journal article
Authors J. Vangipurapu
A. Stancakova
Ulf Smith
J. Kuusisto
M. Laakso
Published in Diabetes
Volume 68
Issue 6
Pages 1353-1358
ISSN 0012-1797
Publication year 2019
Published at Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 1353-1358
Language en
Links dx.doi.org/10.2337/db18-1076
Keywords branched-chain, resistance, hyperglycemia, metabolomics, sensitivity, predictors, metabolism, tolerance, glycemia
Subject categories Endocrinology and Diabetes

Abstract

Several amino acids (AAs) have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but no previous studies have investigated the association of AAs with insulin secretion in a longitudinal setting. Our study included 5,181 participants of the cross-sectional METabolic Syndrome In Men (METSIM) study having metabolomics data on 20 AAs. A total of 4,851 had a 7.4-year follow-up visit. Nine AAs (phenylalanine, tryptophan, tyrosine, alanine, isoleucine, leucine, valine, aspartate, and glutamate) were significantly (P < 5.8 x 10(-5)) associated with decreases in insulin secretion (disposition index) and the elevation of fasting or 2-h glucose levels. Five of these AAs (tyrosine, alanine, isoleucine, aspartate, and glutamate) were also found to be significantly associated with an increased risk of incident type 2 diabetes after adjustment for confounding factors. Our study is the first population-based large cohort to report that AAs are associated not only with insulin resistance but also with decreased insulin secretion.

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