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Activated Peyer's patch B cells sample antigen directly from M cells in the subepithelial dome.

Journal article
Authors Rathan Komban
Anneli Strömberg
Adi Biram
Jakob Cervin
Cristina Lebrero-Fernandez
Neil Mabbott
Ulf Yrlid
Ziv Shulman
Mats Bemark
Nils Y Lycke
Published in Nature communications
Volume 10
Issue 1
Pages 2423
ISSN 2041-1723
Publication year 2019
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Pages 2423
Language en
Keywords Germinal center, Peyer's patch, SED, M cell, B cell
Subject categories Immunology


The germinal center (GC) reaction in Peyer's patches (PP) requires continuous access to antigens, but how this is achieved is not known. Here we show that activated antigen-specific CCR6+CCR1+GL7- B cells make close contact with M cells in the subepithelial dome (SED). Using in situ photoactivation analysis of antigen-specific SED B cells, we find migration of cells towards the GC. Following antigen injection into ligated intestinal loops containing PPs, 40% of antigen-specific SED B cells bind antigen within 2 h, whereas unspecifc cells do not, indicating B cell-receptor involvment. Antigen-loading is not observed in M cell-deficient mice, but is unperturbed in mice depleted of classical dendritic cells (DC). Thus, we report a M cell-B cell antigen-specific transporting pathway in PP that is independent of DC. We propose that this antigen transporting pathway has a critical role in gut IgA responses, and should be taken into account when developing mucosal vaccines.

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