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Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier

Journal article
Authors George M. H. Birchenough
Björn O. Schröder
Fredrik Bäckhed
Gunnar C. Hansson
Published in Gut microbes
Volume 10
Issue 2
Pages 246-250
ISSN 1949-0984
Publication year 2019
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 246-250
Language en
Keywords Colon, diet, fiber, inflammation, microbiota, mucin, mucus, ulcerative colitis
Subject categories Gastroenterology and Hepatology, Immunology in the medical area


It has long been acknowledged that dietary fibres are important to maintain a healthy gut. Over the past decade, several studies have shown that loss of complex polysaccharides from the Western diet has resulted in alterations to our colonic microbiota. The concurrent increase in the incidence of inflammatory bowel disease in the Western world has driven us to explore the potential mechanistic link between diet, the microbiota and the host defence systems that normally prevent inflammation. Using mice fed a low fibre Western-style diet and robust live tissue analytical methods we have now provided evidence that this diet impairs the colonic inner mucus layer that normally separates bacteria from host cells. Western societies urgently need to develop their understanding of the molecular mechanisms of the diet-microbiota-mucus axis and its implications for inflammatory diseases.

Page Manager: Webmaster|Last update: 9/11/2012

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