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A sensitive method detecting trace levels of levonorgestrel using LC-HRMS

Journal article
Authors S. Abujrais
M. Olovsson
Martin Ahnoff
A. J. Rasmusson
A. Larsson
T. Åkerfeldt
K. Kultima
Published in Contraception
Volume 100
Issue 3
Pages 247-249
ISSN 0010-7824
Publication year 2019
Published at Department of marine sciences
Pages 247-249
Language en
Links dx.doi.org/10.1016/j.contraception....
Keywords High resolution mass spectrometry, Intrauterine device, Liquid chromatography, Lower limit of quantification, Solid phase extraction
Subject categories Biochemistry

Abstract

Objective: To develop a high resolution mass spectrometry (HRMS) method to quantify levonorgestrel (LNG) in serum. Study design: Levonorgestrel was extracted using solid phase extraction and measured using liquid chromatography (LC) HRMS. Results: Low limit of quantification (LLOQ) was 25 pg/mL and low limit of detection (LLOD) was 12.5 pg/mL. Precision and accuracy bias were <10%. LNG in serum samples from Mirena® users ranged between 37 to 219 pg/mL (n=12). In eight out of 22 patients with suspected intrauterine device (IUD) expulsion LNG was detected (26–1272 pg/mL). Conclusion: A sensitive, fast and simple LC-HRMS method was developed to detect trace levels of LNG. © 2019 Elsevier Inc.

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