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The impact of comorbidities on mortality among men and women with COPD: report from the OLIN COPD study

Journal article
Authors S. Sawalha
L. Hedman
H. Backman
N. Stenfors
E. Ronmark
Bo Lundbäck
A. Lindberg
Published in Therapeutic Advances in Respiratory Disease
Volume 13
ISSN 1753-4658
Publication year 2019
Published at Krefting Research Centre
Institute of Medicine
Language en
Keywords chronic airflow obstruction, co-morbidity, epidemiology, mortality, sex, obstructive pulmonary-disease, lung-disease, cardiovascular-disease, myocardial-infarction, all-cause, risk, prevalence, determinants, symptoms, heart, Respiratory System
Subject categories Cardiac and Cardiovascular Systems, Internal medicine


Background: Comorbidities probably contribute to the increased mortality observed among subjects with chronic obstructive pulmonary disease (COPD), but sex differences in the prognostic impact of comorbidities have rarely been evaluated in population-based studies. The aim of this study was to evaluate the impact of common comorbidities, cardiovascular disease (CVD), diabetes mellitus (DM), and anxiety/depression (A/D), on mortality among men and women with and without airway obstruction in a population-based study. Methods: All subjects with airway obstruction [forced expiratory volume in 1 second (FEV1)/(forced) vital capacity ((F)VC) <0.70, n = 993] were, together with age- and sex-matched referents, identified after examinations of population-based cohorts in 2002-2004. Spirometric groups: normal lung function (NLF) and COPD (post-bronchodilator FEV1/(F)VC <0.70) and additionally, LLN-COPD (FEV1/(F)VC

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