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Use of Multivariate Immune Reconstitution Patterns to Describe Immune Reconstitution after Allogeneic Stem Cell Transplantation in Children

Journal article
Authors Karin Mellgren
A. F. M. Nierop
Jonas Abrahamsson
Published in Biology of Blood and Marrow Transplantation
Volume 25
Issue 10
Pages 2045-2053
ISSN 1083-8791
Publication year 2019
Published at Institute of Clinical Sciences, Department of Pediatrics
Pages 2045-2053
Language en
Links dx.doi.org/10.1016/j.bbmt.2019.06.0...
Keywords Immune reconstitution, Multivariate analysis, Stem cell transplantation
Subject categories Pediatrics

Abstract

Immune reconstitution after hematopoietic stem cell transplantation (HSCT) is a complex process. Impacts of the reconstitution of different immune cells over time are complex and difficult to understand. New mathematical models are needed to better understand this process. In this study, we used principal component analysis to better analyze the process of immune reconstitution after HSCT. Forty-six consecutive patients receiving HSCT for malignant and nonmalignant disorders were included in the study. All patients were followed for at least 24 months after transplantation with regular blood sampling for analysis of lymphocyte subset numbers and function. Exponentially transformed lymphocyte subset counts and lymphocyte functional markers were analyzed to identify major trends in the reconstitution process. Using our multivariate model for mapping immune reconstitution after HSCT, we showed that dysfunctional reconstitution patterns precede severe complications, such as chronic graft-versus-host disease, relapse, and death. © 2019 American Society for Blood and Marrow Transplantation

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