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Effects of fibrinogen supplementation on clot formation in blood samples from cardiac surgery patients before and after tranexamic acid administration

Journal article
Authors Katarina Waldén
Caroline Andersson Shams Hakimi
Anders Jeppsson
Martin Karlsson
Published in Transfusion Medicine
Volume 29
Issue 5
Pages 319-324
ISSN 0958-7578
Publication year 2019
Published at Institute of Clinical Sciences, Department of Anesthesiology and Intensive care
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 319-324
Language en
Links dx.doi.org/10.1111/tme.12604
Keywords cardiac surgery, cardiopulmonary bypass, coagulopathy, fibrinogen, haemodilution, tranexamic acid
Subject categories Anesthesiology and Intensive Care, Cardiac and Cardiovascular Systems

Abstract

Objectives: To investigate if supplementation with fibrinogen concentrate to blood samples collected after tranexamic acid administration improve clot formation more than what can be achieved with fibrinogen in the absence of tranexamic acid. Background: It is not known if the combination of fibrinogen and tranexamic acid has additional effects than what can be achieved individually. Methods: Four blood samples were collected from 15 coronary artery bypass patients. Two samples were collected before surgery, before and after 2 g tranexamic acid was administered. The preoperative samples were diluted to haematocrit 21%. Two samples were collected after surgery, before and after a second dose of 2 g tranexamic acid. Fibrinogen concentrate corresponding to a dose of 3 g in a 70-kg patient was added to the samples. Platelet-independent clotting time and maximum clot firmness assessed by thromboelastometry (ROTEM-FIBTEM®) were compared between the samples. Results: Administration of tranexamic acid shortened clotting time marginally (−6%) before surgery, P = 0·029) but did not influence clot firmness. Fibrinogen concentrate shortened clotting time (−14% before and −12% after surgery, both P = 0·003) and increased clot firmness (+51 and +39%, both P < 0·001). The effects of fibrinogen did not differ before and after tranexamic acid administration. Fibrinolysis was not detected in any sample. Conclusions: The results of this in vitro study suggest that the enhancing effects of fibrinogen on clot firmness in blood samples from cardiac surgery patients are not further increased in the presence of tranexamic acid. Further studies on patients with ongoing bleeding and/or hyperfibrinolysis are necessary to validate the results. © 2019 British Blood Transfusion Society

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