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The intestinal flora is required for post-transplant hematopoiesis in recipients of a hematopoietic stem cell transplantation

Journal article
Authors Anna Staffas
M. van den Brink
Published in Bone Marrow Transplantation
Volume 54
Pages 756-758
ISSN 0268-3369
Publication year 2019
Published at Sahlgrenska Cancer Center
Institute of Biomedicine, Department of Microbiology and Immunology
Pages 756-758
Language en
Links dx.doi.org/10.1038/s41409-019-0612-...
Keywords microbiota, granulopoiesis, nod1, Biophysics, Oncology, Hematology, Immunology, Transplantation
Subject categories Biophysics, Immunology in the medical area, Hematology, Cancer and Oncology

Abstract

Recent studies in both mice and humans have demonstrated that the intestinal microbiota can affect hematopoiesis. Here, we performed experiments in preclinical mouse models for syngeneic and allogeneic HCT. To study the metabolic effects of intestinal flora depletion on post-transplant hematopoiesis in humans, we performed HCT experiments using a metabolic chamber and bomb calorimetry of feces. Taken together, we show that the intestinal microbiota supports post-transplant hematopoietic reconstitution in HCT recipients through its role in dietary energy uptake.

Page Manager: Webmaster|Last update: 9/11/2012
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