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The gut microbiota is a major regulator of androgen metabolism in intestinal contents.

Journal article
Authors Hannah Colldén
Andreas Landin
Ville Wallenius
Erik Elebring
Lars Fändriks
Maria E. Nilsson
Henrik Ryberg
Matti Poutanen
Klara Sjögren
Liesbeth Vandenput
Claes Ohlsson
Published in American journal of physiology. Endocrinology and metabolism
Volume 317
Issue 6
Pages E1182-E1192
ISSN 1522-1555
Publication year 2019
Published at Centre for Bone and Arthritis Research
Institute of Clinical Sciences, Department of Gastrosurgical Research and Education
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages E1182-E1192
Language en
Links dx.doi.org/10.1152/ajpendo.00338.20...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Endocrinology

Abstract

Androgens exert important effects both in androgen-responsive tissues and in the intestinal tract. To determine the impact of the gut microbiota (GM) on intestinal androgen metabolism, we measured unconjugated (free) and glucuronidated androgen levels in intestinal contents from the small intestine, with a low bacterial density, and from cecum and colon, with a high bacterial density. Using a specific, sensitive gas chromatography-tandem mass spectrometry method, we detected high levels of glucuronidated testosterone (T) and dihydrotestosterone (DHT) in small intestinal content of mice of both sexes, whereas in the distal intestine we observed remarkably high levels of free DHT, exceeding serum levels by >20-fold. Similarly, in young adult men high levels of unconjugated DHT, >70-fold higher than in serum, were detected in feces. In contrast to mice with a normal GM composition, germ-free mice had high levels of glucuronidated T and DHT, but very low free DHT levels, in the distal intestine. These findings demonstrate that the GM is involved in intestinal metabolism and deglucuronidation of DHT and T, resulting in extremely high free levels of the most potent androgen, DHT, in the colonic content of young and healthy mice and men.

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