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An update on fluid biomarkers for neurodegenerative diseases: recent success and challenges ahead.

Journal article
Authors Joel Simrén
Nicholas Ashton
Kaj Blennow
Henrik Zetterberg
Published in Current opinion in neurobiology
Volume 61
Pages 29-39
ISSN 1873-6882
Publication year 2019
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Wallenberg Centre for Molecular and Translational Medicine
Pages 29-39
Language en
Links dx.doi.org/10.1016/j.conb.2019.11.0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Neurochemistry, Neuroscience, Neurobiology

Abstract

Over the last twenty years, the characterization of Alzheimer's disease (AD) patients has progressed from a description of clinical symptomatology followed by neuropathological findings at autopsy to in vivo pathophysiological signatures using cerebrospinal fluid (CSF) and positron emission tomography (PET). Additionally, CSF biomarkers now reflect synaptic pathology, axonal injury and neuroinflammation. Novel techniques are capable of measuring proteins of pathophysiological importance at femtomolar concentrations in blood (e.g. amyloid, tau species and neurofilaments), which enable screening of large populations in the near future. This will be essential for secondary prevention trials and clinical management. However, common diseases such as dementia with Lewy bodies, Parkinson's disease and frontotemporal dementias, are still without reliable diagnostic biomarkers, although emerging techniques show promising pilot results for some of these diseases. This is likely to change in the next few years, which will be crucial to stratify populations enrolling in clinical trials, since pathologies often coexist.

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