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Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa.

Journal article
Authors Gasper Maeda
Jelle van der Wal
Arvind Kumar Gupta
Joan J E Munissi
Andreas Orthaber
Per Sunnerhagen
Stephen S Nyandoro
Mate Erdelyi
Published in Journal of natural products
Volume 83
Issue 2
Pages 210-215
ISSN 0163-3864
Publication year 2020
Published at Department of Chemistry and Molecular Biology
Centre for antibiotic resistance research, CARe
Pages 210-215
Language en
Links dx.doi.org/10.1021/acs.jnatprod.9b0...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Pharmacognosy, Pharmaceutical microbiology, Bacteriology

Abstract

Three new oxygenated cyclohexene derivatives, trichocarpeols A (1), B (2), and C (3), along with nine known secondary metabolites, were isolated from the methanolic root extract of Monanthotaxis trichocarpa. They were identified by NMR spectroscopic and mass spectrometric analyses, and the structure of trichocarpeol A (1) was confirmed by single-crystal X-ray diffraction. Out of the 12 isolated natural products, uvaretin (4) showed activity against the Gram-positive bacterium Bacillus subtilis with a MIC value of 18 μM. None of the isolated metabolites was active against the Gram-negative Escherichia coli at a ∼5 mM (2000 μg/mL) concentration. Whereas 4 showed cytotoxicity at EC50 10.2 μM against the MCF-7 human breast cancer cell line, the other compounds were inactive or not tested.

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