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Circulating cell-free DNA: Translating prostate cancer genomics into clinical care.

Journal article
Authors Delila Gasi Tandefelt
Johann de Bono
Published in Molecular aspects of medicine
Volume 72
Pages 100837
ISSN 1872-9452
Publication year 2020
Published at Sahlgrenska Cancer Center
Pages 100837
Language en
Links dx.doi.org/10.1016/j.mam.2019.10083...
www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Cancer and Oncology, Urology and Nephrology

Abstract

Only in the past decade tremendous advances have been made in understanding prostate cancer genomics and consequently in applying new treatment strategies. As options regarding treatments are increasing so are the challenges in selecting the right treatment option for each patient and not the least, understanding the optimal time-point and sequence of applying available treatments. Critically, without reliable methods that enable sequential monitoring of evolving genotypes in individual patients, we will never reach effective personalised driven treatment approaches. This review focuses on the clinical implications of prostate cancer genomics and the potential of cfDNA in facilitating treatment management.

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