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Cellular and molecular reactions to dental implants

Chapter in book
Authors Omar Omar
Furqan A. Shah
Krisztina Ruscsák
Shariel Sayardoust
Anders Palmquist
Peter Thomsen
Published in Dental Implants and Bone Grafts. Materials and Biological Issues. Hamdan Alghamdi and John Jansen (red.)
Pages 183-205
ISBN 978-0-08-102478-2
Publisher Elsevier
Publication year 2020
Published at Institute of Clinical Sciences, Department of Biomaterials
Pages 183-205
Language en
Keywords Osseointegration, Dental implants, Mechanisms, Cell recruitment, Inflammation, Bone formation, Bone remodeling, Cytokines, Growth factors, Osteogenic differentiation
Subject categories Biomaterials Science


This chapter provides an overview of the cellular interactions and the genetic regulations at the bone-implant interface, based on experimental in vivo studies and the available studies in humans. The first part discusses the current knowledge on the cellular and molecular events governing the initial cell recruitment, early inflammation, and the transition from inflammation to bone formation and remodeling during the phases of osseointegration. The modulation of these events, by different implant surfaces, and their relationship with the structural and functional development of the interface, are emphasized. A subsequent section is focused on selected key biological factors, potentially involved in the osteogenic differentiation of mesenchymal stem cells or in coupling of bone formation and remodeling at the interface. Further, possible phenotypic polarizations of macrophages at the interface, in vivo, is discussed. Finally, some insights on possible dysregulations of the molecular activities at the interface, under selected bone-compromising conditions, are provided.

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