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Intra-individual variation of particles in exhaled air and of the contents of Surfactant protein A and albumin

Journal article
Authors Spela Kokelj
Jeong-Lim Kim
Marianne Andersson
Gunilla Runström Eden
Björn Bake
Anna-Carin Olin
Published in PLoS ONE
Volume 15
Issue 1
Publication year 2020
Published at Institute of Medicine, School of Public Health and Community Medicine
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Language en
Links https://doi.org/10.1371/journal.pon...
Subject categories Respiratory Medicine and Allergy

Abstract

© 2020 Kokelj et al. Introduction Particles in exhaled air (PEx) provide samples of respiratory tract lining fluid from small airways containing, for example, Surfactant protein A (SP-A) and albumin, potential biomarkers of small airway disease. We hypothesized that there are differences between morning, noon, and afternoon measurements and that the variability of repeated measurements is larger between days than within days. Methods PEx was obtained in sixteen healthy non-smoking adults on 11 occasions, within one day and between days. SP-A and albumin were quantified by ELISA. The coefficient of repeatability (CR), intraclass correlation coefficient (ICC), and coefficient of variation (CV) were used to assess the variation of repeated measurements. Results SP-A and albumin increased significantly from morning towards the noon and afternoon by 13% and 25% on average, respectively, whereas PEx number concentration and particle mean mass did not differ significantly between the morning, noon and afternoon. Betweenday CRs were not larger than within-day CRs. Conclusions Time of the day influences the contents of SP-A and albumin in exhaled particles. The variation of repeated measurements was rather high but was not influenced by the time intervals between measurements.

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