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Parkinson's disease - heterogeneous and complex in its clinical presentation

Journal article
Authors Filip Bergquist
A. Johansson
N. Dizdar
H. Widner
D. Nyholm
P. Odin
P. Svenningsson
Published in Läkartidningen
Volume 9
Issue 117
ISSN 16527518
Publication year 2020
Published at Institute of Neuroscience and Physiology
Language sv
Subject categories Neurosciences

Abstract

Parkinson's disease is the second most common neurodegenerative disease. Lewy bodies with alpha-synuclein as the major component and loss of dopaminergic nerve cells in substantia nigra are neuropathological features. The diagnosis of Parkinson's disease is based on the occurrence of bradykinesia, rigidity and resting tremor. The disease is also associated with several non-motor symptoms. The therapy is mainly based on pharmacological treatment to increase dopamine signaling and neurosurgical deep brain stimulation. The symptoms and signs of the progressive disease change over time, requiring treatment adjustments. Patients should be followed by a physician, nurse and a multidisciplinary team with expertise in Parkinson's disease.

Page Manager: Webmaster|Last update: 9/11/2012
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