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Cartilage oligomeric matrix protein increases in serum after the start of growth hormone treatment in prepubertal children

Journal article
Authors Ragnar Bjarnason
Björn Andersson
Hye Sook Kim
Bob Olsson
Diana Swolin-Eide
Ruth Wickelgren
Berit Kriström
Björn Carlsson
Kerstin Albertsson-Wikland
Lena M S Carlsson
Published in Journal of Clinical Endocrinology and Metabolism
Volume 89
Issue 10
Pages 5156-60
Publication year 2004
Published at Institute for the Health of Women and Children, Dept of Paediatrics
Institute of Internal Medicine, Dept of Body Composition and Metabolism
Pages 5156-60
Language en
Links www.ncbi.nlm.nih.gov/sites/entrez?c...
Subject categories Endocrinology, Pediatrics

Abstract

Both GH and IGF-I stimulate bone growth, but the molecular mechanisms mediating their effects on the growth plate are not fully understood. We measured gene expression by microarray analysis in primary cultured human chondrocytes treated with either GH or IGF-I. One of the genes found to be up-regulated by both GH and IGF-I was that encoding cartilage oligomeric matrix protein (COMP). This protein is predominantly found in the extracellular matrix of cartilage. Mutations in the COMP gene have been associated with syndromes of short stature. To verify that COMP is regulated by GH in vivo, we measured COMP levels in serum in short children treated with GH. The study included 113 short prepubertal children (14 girls and 99 boys) with a mean (+/- sd) age of 8.84 +/- 2.76 yr, height sd score of -2.74 +/- 0.67, and IGF-I sd score of -1.21 +/- 1.07 at the start of GH administration. Serum levels of COMP were 1.58 +/- 0.28, 1.83 +/- 0.28 (P < 0.0001), 1.91 +/- 0.28 (P < 0.0001), 1.78 +/- 0.28 (P < 0.001), and 1.70 +/- 0.24 (P < 0.05) microg/ml at baseline and after 1 wk and 1, 3, and 12 months, respectively.In conclusion, we have demonstrated that COMP expression is up-regulated by both GH and IGF-I in primary cultured human chondrocytes. Furthermore, serum levels of COMP increase after the start of GH treatment in short children.

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