To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Fusion oncogenes in tumor… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Fusion oncogenes in tumor development.

Review article
Authors Pierre Åman
Published in Seminars in cancer biology
Volume 15
Issue 3
Pages 236-43
ISSN 1044-579X
Publication year 2005
Published at Institute of Laboratory Medicine, Dept of Pathology
Pages 236-43
Language en
Keywords Animals, Chromatin, genetics, DNA Damage, genetics, DNA Repair, genetics, Humans, Neoplasms, classification, genetics, metabolism, pathology, Oncogene Proteins, Fusion, genetics, metabolism, Transcription, Genetic, genetics
Subject categories Medical and Health Sciences


Currently, all identified fusion oncogenes are found in rare tumor forms, and most of them only in specific tumor types. Some fusion oncogenes are frequent in healthy individuals suggesting that they rarely induce tumor growth. Multiple double-strand breaks that cluster in time and space increases the risk for formation of fusion oncogenes genes. The normal cell type specific spatial distribution of chromatin and genes in interphase nuclei may affect the risk for fusion of specific genes. Transcriptional orientation, splicing of reading frames, size and sequences of breakpoint introns are other risk factors. The biological activity of fusion oncoproteins is the most important factor for penetrance. The effects in specific target cells may explain the tumor type specificity of most fusion oncogenes.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?