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Hypothyroidism is common in turner syndrome: results of a five-year follow-up.

Journal article
Authors Mohamed Mostafa El-Mansoury
Inger Bryman
Kerstin Berntorp
Charles Hanson
Lars Wilhelmsen
Kerstin Landin-Wilhelmsen
Published in The Journal of clinical endocrinology and metabolism
Volume 90
Issue 4
Pages 2131-5
ISSN 0021-972X
Publication year 2005
Published at Institute for the Health of Women and Children
Cardiovascular Institute
Institute for the Health of Women and Children, Dept of Obstetrics and Gynaecology
Institute of Internal Medicine
Pages 2131-5
Language en
Keywords Adolescent, Adult, Aged, Female, Follow-Up Studies, Humans, Hypothyroidism, etiology, In Situ Hybridization, Fluorescence, Iodide Peroxidase, blood, Middle Aged, Mosaicism, Thyrotropin, blood, Turner Syndrome, complications, genetics
Subject categories Medical and Health Sciences


Turner syndrome (TS) is caused by a sex chromosome aberration. The aim was to study the prevalence and incidence of thyroid disease in adults with TS. Women with TS (n = 91; mean age, 37.7 +/- 11 yr) were compared with an age-matched female random population sample (n = 228). At baseline, 15 (16%) TS women were treated for hypothyroidism, and elevated serum TSH was found in another eight (9%). As a result, hypothyroidism was more common in women with TS (25%) than in controls (2%; P < 0.0001). Serum free T4 was lower (P = 0.02), and serum TSH was higher (P < 0.0001) in TS women than in age-matched controls. Of all TS women with hypothyroidism, 10 (43%) had an elevated thyroid peroxidase antibody titer vs. 15 (22%) of those without hypothyroidism (P < 0.05), evenly distributed between the karyotype 45,X and mosaicism. A high body mass index, but not a family history or blood lipids, was associated with hypothyroidism in TS. After the 5-yr follow-up, an additional 11 (16%) developed hypothyroidism, of whom four (36%) had elevated thyroid peroxidase. Altogether, 34 (37%) TS women had hypothyroidism after the 5-yr follow-up. Autoimmune hypothyroidism was common, with an annual incidence of 3.2% in TS. Thyroid function should be checked regularly in TS.

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