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Regional assignment of the human 4-hydroxyphenylpyruvate dioxygenase gene (HPD) to 12q24-->qter by fluorescence in situ hybridization.

Journal article
Authors Göran Stenman
E Röijer
Ulla Rüetschi
A Dellsén
Lars Rymo
Sven Lindstedt
Published in Cytogenetics and cell genetics
Volume 71
Issue 4
Pages 374-6
ISSN 0301-0171
Publication year 1995
Published at Institute of Laboratory Medicine, Dept of Pathology
Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
Pages 374-6
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords 4-Hydroxyphenylpyruvate Dioxygenase, genetics, Animals, Base Sequence, Blotting, Southern, Chromosome Mapping, Chromosomes, Human, Pair 12, genetics, ultrastructure, DNA, Complementary, Exons, genetics, Humans, In Situ Hybridization, Fluorescence, Mice, Molecular Sequence Data
Subject categories Cell and molecular biology

Abstract

Using a panel of human-rodent somatic cell hybrids, we have previously mapped the gene (HPD, previously called PPD) encoding 4-hydroxyphenylpyruvate dioxygenase to the distal half of the long arm of human chromosome 12, region q14-->qter. To obtain a genomic probe useful for fluorescence in situ hybridization (FISH) analysis we screened a human leukocyte genomic library and isolated a 13.4-kb phage clone, which by restriction fragment and sequence analyses was shown to contain exons 1-10 of HPD and approximately 2-kb upstream sequences. We now report the subregional localization of HPD to 12q24-->qter based on two color FISH analysis employing this clone.

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