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Foxc2 is essential for podocyte function.

Journal article
Authors Daniel Nilsson
Mikael Heglind
Zahra Arani
Sven Enerbäck
Published in Physiological reports
Volume 7
Issue 9
Pages e14083
ISSN 2051-817X
Publication year 2019
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages e14083
Language en
Links dx.doi.org/10.14814/phy2.14083
www.ncbi.nlm.nih.gov/entrez/query.f...
Keywords Foxc2 Nrp1 podocyte proteinuria
Subject categories Histology, Medical cell biology, Molecular medicine (genetics and pathology), Animal physiology, Morphology, Molecular biology, Genetics, Cell Biology

Abstract

Foxc2 is one of the earliest podocyte markers during glomerular development. To circumvent embryonic lethal effects of global deletion of Foxc2, and to specifically investigate the role of Foxc2 in podocytes, we generated mice with a podocyte-specific Foxc2 deletion. Mice carrying the homozygous deletion developed early proteinuria which progressed rapidly into end stage kidney failure and death around postnatal day 10. Conditional loss of Foxc2 in podocytes caused typical characteristics of podocyte injury, such as podocyte foot process effacement and podocyte microvillus transformation, probably caused by disruption of the slit diaphragm. These effects were accompanied by a redistribution of several proteins known to be necessary for correct podocyte structure. One target gene that showed reduced glomerular expression was Nrp1, the gene encoding neuropilin 1, a protein that has been linked to diabetic nephropathy and proteinuria. We could show that NRP1 was regulated by Foxc2 in vitro, but podocyte-specific ablation of Nrp1 in mice did not generate any phenotype in terms of proteinuria, suggesting that the gene might have more important roles in endothelial cells than in podocytes. Taken together, this study highlights a critical role for Foxc2 as an important gene for podocyte function.

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Utskriftsdatum: 2019-10-19