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Both lewis and secretor status mediate susceptibility to rotavirus infections in a rotavirus genotype-dependent manner.

Journal article
Authors Johan Nordgren
Sumit Sharma
Filemon Bucardo
Waqas Nasir
Gökçe Günaydın
Djeneba Ouermi
Leon W Nitiema
Sylvia Becker-Dreps
Jacques Simpore
Lennart Hammarström
Göran Larson
Lennart Svensson
Published in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume 59
Issue 11
Pages 1567-73
ISSN 1537-6591
Publication year 2014
Published at Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Pages 1567-73
Language en
Subject categories Infectious Medicine, Clinical Laboratory Medicine


The live oral rotavirus (RV) vaccines have shown a reduced efficacy in Africa. Recent in vitro studies have shown binding of the RV surface protein (VP4) to histo-blood group antigens (HBGAs) in an RV genotype-dependent manner, suggesting them to be putative receptors for RV. The diversity of HBGA phenotypes in different ethnic populations, combined with prevalence/absence of specific RV genotypes, led us to hypothesize whether the genetic variations in HBGAs in a population limit susceptibility to certain RV genotypes, plausibly leading to reduced vaccine efficacy.

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