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BMI and Mortality in Patients With New-Onset Type 2 Diabetes: A Comparison With Age- and Sex-Matched Control Subjects From the General Population

Journal article
Authors Jon Edqvist
Araz Rawshani
Martin Adiels
Lena Björck
Marcus Lind
A. M. Svensson
S. Gudbjornsdottir
N. Sattar
Annika Rosengren
Published in Diabetes Care
Volume 41
Issue 3
Pages 485-493
ISSN 1935-5548
Publication year 2018
Published at Institute of Medicine, School of Public Health and Community Medicine
Institute of Medicine
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages 485-493
Language en
Keywords Adult, Age of Onset, Aged, Aged, 80 and over, *Body Mass Index, Body Weight, Case-Control Studies, Diabetes Mellitus, Type 2/complications/metabolism/*mortality, Female, Humans, Male, Middle Aged, Obesity/complications/epidemiology/mortality, Overweight/complications/epidemiology/mortality, Risk Factors, Sweden/epidemiology
Subject categories Clinical Medicine


OBJECTIVE: Type 2 diabetes is strongly associated with obesity, but the mortality risk related to elevated body weight in people with type 2 diabetes compared with people without diabetes has not been established. RESEARCH DESIGN AND METHODS: We prospectively assessed short- and long-term mortality in people with type 2 diabetes with a recorded diabetes duration /=40 kg/m(2) compared with control subjects after multiple adjustments. Long-term, all weight categories showed increased mortality, with a nadir at BMI 25 to <30 kg/m(2) and a stepwise increase up to HR 2.00 (95% CI 1.58-2.54) among patients with BMI >/=40 kg/m(2), that was more pronounced in patients <65 years old. CONCLUSIONS: Our findings suggest that the apparent paradoxical findings in other studies in this area may have been affected by reverse causality. Long-term, overweight (BMI 25 to <30 kg/m(2)) patients with type 2 diabetes had low excess mortality risk compared with control subjects, whereas risk in those with BMI >/=40 kg/m(2) was substantially increased.

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