Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Radiation-induced genomic… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Radiation-induced genomic instability in breast carcinomas of the Swedish haemangioma cohort.

Artikel i vetenskaplig tidskrift
Författare Jana Biermann
Britta Langen
Szilard Nemes
Erik Holmberg
Toshima Z Parris
Elisabeth Werner Rönnerman
Hanna Engqvist
Anikó Kovács
Khalil Helou
Per Karlsson
Publicerad i Genes, chromosomes & cancer
Volym 58
Nummer/häfte 9
Sidor 627-35
ISSN 1098-2264
Publiceringsår 2019
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för radiofysik
Institutionen för kliniska vetenskaper, Avdelningen för onkologi
Sahlgrenska Cancer Center
Sidor 627-35
Språk en
Länkar dx.doi.org/10.1002/gcc.22757
www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Radiation-induced genomic instability; Swedish haemangioma cohort; breast irradiation; cancer genome instability; long-term radiation effects
Ämneskategorier Cancer och onkologi, Bioinformatik (beräkningsbiologi), Biologiska vetenskaper

Sammanfattning

Radiation-induced genomic instability (GI) is hypothesized to persist after exposure and ultimately promote carcinogenesis. Based on the absorbed dose to the breast, an increased risk of developing breast cancer was shown in the Swedish haemangioma cohort that was treated with radium-226 for skin haemangioma as infants. Here, we screened 31 primary breast carcinomas for genetic alterations using the OncoScan CNV Plus Assay to assess GI and chromothripsis-like patterns associated with the absorbed dose to the breast. Higher absorbed doses were associated with increased numbers of copy number alterations (CNAs) in the tumour genome and thus a more unstable genome. Hence, the observed dose-dependent GI in the tumour genome is a measurable manifestation of the long-term effects of irradiation. We developed a highly predictive Cox regression model for overall survival based on the interaction between absorbed dose and GI. The Swedish haemangioma cohort is a valuable cohort to investigate the biological relationship between absorbed dose and GI in irradiated humans. This work gives a biological basis for improved risk assessment to minimize carcinogenesis as a secondary disease after radiation therapy. This article is protected by copyright. All rights reserved.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?