Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Complete Coding Regions o… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Complete Coding Regions of the Prototypes Enterovirus B93 and C95: Phylogenetic Analyses of the P1 and P3 Regions of EV-B and EV-C Strains

Artikel i vetenskaplig tidskrift
Författare N. Junttila
N. Leveque
L. O. Magnius
J. P. Kabue
J. J. Muyembe-Tamfum
J. Maslin
B. Lina
Helene Norder
Publicerad i Journal of Medical Virology
Volym 87
Nummer/häfte 3
Sidor 485-497
ISSN 0146-6615
Publiceringsår 2015
Publicerad vid Institutionen för biomedicin, avdelningen för infektionssjukdomar
Sidor 485-497
Språk en
Länkar dx.doi.org/10.1002/jmv.24062
Ämnesord enterovirus, species, recombination, P3 gene, P1 gene, COMMUNITY-ACQUIRED PNEUMONIA, FREQUENT RECOMBINATION, MOLECULAR-IDENTIFICATION, UNTYPABLE ENTEROVIRUSES, RNA RECOMBINATION, GENOMIC ANALYSIS, VP1 SEQUENCE, EVOLUTION, SEROTYPES, VIRUSES, Virology
Ämneskategorier Klinisk virologi

Sammanfattning

Complete coding regions were sequenced for two new enterovirus genomes: EV-B93 previously identified by VP1 sequencing, derived from a child with acute flaccid paralysis in the Democratic Republic of Congo; and EV-C95 from a French soldier with acute gastroenteritis in Djibouti. The EV-B93 P1 had more than 30% nucleotide divergence from other EV-B types, with highest similarity to E-15 and EV-B80. The P1 nucleotide sequence of EV-C95 was most similar, 71%, to CV-A21. Complete coding regions for the new enteroviruses were compared with those of 135 EV-B and 176 EV-C strains representing all types available in GenBank. When strains from the same outbreak or strains isolated during the same year in the same geographical region were excluded, 27 of the 58 EV-B, and 16 of the 23 EV-C types were represented by more than one sequence. However, for EV-B the P3 sequences formed three clades mainly according to origin or time of isolation, irrespective of type, while for EV-C the P3 sequences segregated mainly according to disease manifestation, with most strains causing paralysis, including polioviruses, forming one clade, and strains causing respiratory illness forming another. There was no intermixing of types between these two clades, apart from two EV-C96 strains. The EV-B P3 sequences had lower inter-clade and higher intra-clade variability as compared to the EV-C sequences, which may explain why inter-clade recombinations are more frequent in EV-B. Further analysis of more isolates may shed light on the role of recombinations in the evolution of EV-B in geographical context. J. Med. Virol. 87:485-497, 2015. (c) 2014 Wiley Periodicals, Inc.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?

Denna text är utskriven från följande webbsida:
http://gu.se/forskning/publikation/?publicationId=213435
Utskriftsdatum: 2020-08-11