Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Genetic Imbalance Is Asso… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Genetic Imbalance Is Associated With Functional Outcome After Ischemic Stroke

Artikel i vetenskaplig tidskrift
Författare D. Pfeiffer
B. Chen
K. Schlicht
P. Ginsbach
S. Abboud
A. Bersano
S. Bevan
T. Brandt
V. Caso
S. Debette
P. Erhart
S. Freitag-Wolf
G. Giacalone
A. J. Grau
E. Hayani
Christina Jern
J. Jimenez-Conde
M. Kloss
M. Krawczak
J. M. Lee
R. Lemmens
D. Leys
C. Lichy
J. M. Maguire
J. J. Martin
A. J. Metso
T. M. Metso
B. D. Mitchell
A. Pezzini
J. Rosand
N. S. Rost
M. Stenman
Turgut Tatlisumak
V. Thijs
E. Touze
C. Traenka
I. Werner
D. Woo
E. Del Zotto
S. T. Engelter
S. J. Kittner
J. W. Cole
C. Grond-Ginsbach
P. A. Lyrer
A. Lindgren
Publicerad i Stroke
Volym 50
Nummer/häfte 2
Sidor 298-304
ISSN 0039-2499
Publiceringsår 2019
Publicerad vid Institutionen för neurovetenskap och fysiologi
Sidor 298-304
Språk en
Länkar dx.doi.org/10.1161/strokeaha.118.02...
Ämnesord DNA copy number variations, genetics, polymorphism, single nucleotide, prognosis, stroke, copy-number variation, genome-wide, ohnologs, risk
Ämneskategorier Neurovetenskaper

Sammanfattning

Background and Purpose-We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods-Copy number variation was identified in high-density single-nucleotide polymorphism microarray data of IS patients from the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) and SiGN (Stroke Genetics Network)/ GISCOME (Genetics of Ischaemic Stroke Functional Outcome) networks. Genetic imbalance, defined as total number of protein-coding genes affected by copy number variations in an individual, was compared between patients with favorable (modified Rankin Scale score of 0-2) and unfavorable (modified Rankin Scale score of = 3) outcome after 3 months. Subgroup analyses were confined to patients with imbalance affecting ohnologs-a class of dose-sensitive genes, or to those with imbalance not affecting ohnologs. The association of imbalance with outcome was analyzed by logistic regression analysis, adjusted for age, sex, stroke subtype, stroke severity, and ancestry. Results-The study sample comprised 816 CADISP patients (age 44.2 +/- 10.3 years) and 2498 SiGN/GISCOME patients (age 67.7 +/- 14.2 years). Outcome was unfavorable in 122 CADISP and 889 SiGN/GISCOME patients. Multivariate logistic regression analysis revealed that increased genetic imbalance was associated with less favorable outcome in both samples (CADISP: P=0.0007; odds ratio=0.89; 95% CI, 0.82-0.95 and SiGN/GISCOME: P=0.0036; odds ratio=0.94; 95% CI, 0.91-0.98). The association was independent of age, sex, stroke severity on admission, stroke subtype, and ancestry. On subgroup analysis, imbalance affecting ohnologs was associated with outcome (CADISP: odds ratio=0.88; 95% CI, 0.80-0.95 and SiGN/GISCOME: odds ratio=0.93; 95% CI, 0.89-0.98) whereas imbalance without ohnologs lacked such an association. Conclusions-Increased genetic imbalance was associated with poorer functional outcome after IS in both study populations. Subgroup analysis revealed that this association was driven by presence of ohnologs in the respective copy number variations, suggesting a causal role of the deleterious effects of genetic imbalance.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?

Denna text är utskriven från följande webbsida:
http://gu.se/forskning/publikation/?publicationId=281732
Utskriftsdatum: 2019-09-20