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Quality of life in patients treated for anal carcinoma-a systematic literature review

Artikel i vetenskaplig tidskrift
Författare Anton Sterner
Kristoffer Derwinger
C. Staff
Hanna Nilsson
Eva Angenete
Publicerad i International Journal of Colorectal Disease
Volym 34
Nummer/häfte 9
Sidor 1517-1528
ISSN 0179-1958
Publiceringsår 2019
Publicerad vid Institutionen för kliniska vetenskaper, Avdelningen för kirurgi
Sidor 1517-1528
Språk en
Länkar dx.doi.org/10.1007/s00384-019-03342...
Ämnesord Anal cancer, Oncology, Morbidity, Radiotherapy, questionnaire eortc qlq-c30, rectal-cancer, functional assessment, combined therapy, fact-c, sexual dysfunction, colorectal-cancer, urinary, radiotherapy, reliability, Gastroenterology & Hepatology, Surgery
Ämneskategorier Cancer och onkologi, Gastroenterologi

Sammanfattning

Purpose Anal cancer is a mainly treated with chemoradiotherapy. A small number of patients undergo salvage surgery. There are few published studies investigating quality of life and functional outcome after treatment for anal cancer. The aim of this review was to explore the literature and identify areas for further research. Methods A search was conducted in Medline using MESH terms related to anal cancer and quality of life. Two investigators selected and reviewed articles based on titles and abstracts. Three investigators read and reviewed the included articles and collected relevant data. The included articles were evaluated using the minimum standard checklist, and key findings were summarised in a chart. Results Some 15 articles, and a total of 802 patients, were deemed eligible. The results differed slightly among the studies. The incidence of symptoms such as fatigue, nausea, insomnia and appetite loss was higher than among healthy volunteers. Bowel function, urinary function and sexual function were negatively affected. Some studies found that, compared with the normal population, anal cancer survivors scored clinically significant worse in the functional scales in QLQ-C30. Conclusion In conclusion, it is apparent that several functional problems affect the quality of life of patients with anal cancer. There are few studies which have investigated quality of life after treatment for anal cancer. Interventions to address issues related to anal cancer treatment may improve long-term quality of life in this patient group.

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http://gu.se/forskning/publikation/?publicationId=283976
Utskriftsdatum: 2019-11-13