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The IGF system and longitudinal growth in preterm infants in relation to gestational age, birth weight and gender

Artikel i vetenskaplig tidskrift
Författare Ann Hellström
J. Sigurdsson
Chatarina Löfqvist
Gunnel Hellgren
A. Kistner
Publicerad i Growth Hormone & Igf Research
Volym 51
Sidor 46-57
ISSN 1096-6374
Publiceringsår 2020
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för biomedicin
Institutionen för vårdvetenskap och hälsa
Sidor 46-57
Språk en
Länkar dx.doi.org/10.1016/j.ghir.2020.02.0...
Ämnesord Preterm children, IGF-I, IGF-II, IGFBP-I, ALS, acid-labile subunit, factor-i, binding protein-1, postnatal-growth, insulin, retinopathy, prematurity, leptin, deficiency, variables, Cell Biology, Endocrinology & Metabolism
Ämneskategorier Pediatrik, Neurologi

Sammanfattning

Objective: Growth factors in the blood of very preterm infants may reflect growth and contribute to the understanding of early development. We investigated postnatal levels of insulin-like growth factors (IGFs) in infants born very preterm and related them to early growth development. Design: Blood samples were analyzed weekly for IGF-I, IGF-II, IGF binding protein (BP)-1, IGFBP-3, and acid-label subunit (ALS). Methods: 73 children born very preterm (gestational age (GA) < 32 weeks) were divided according to their gender-specific birth weight standard deviation score (SDS) into either appropriate for GA (AGA) or small for GA (SGA). Fifty-two (71%) and forty-three (59%) infants completed follow-up with anthropometry at approximately 3 years and at 5 years of age respectively. Thirty-six subjects (49%) had blood sampling for IGF-I and IGFBP-3 measurements up to 3 years of age. Results: IGF-I, IGFBP-3, and ALS levels increased in all groups from week 31 to week 36, with generally lower levels in the SGAs, with a concomitant lower growth velocity. Postnatal ALS was strongly associated with IGF-I and IGFBP-3 in boys, girls and AGA infants. IGF-II was higher in earlier born preterms (GA < 27 weeks) at postmenstrual ages 27.5-29.9 weeks compared with SGAs and late GA (GA >= 27 weeks) preterms (p <.0001). IGF-II, in contrast to IGF-I, did not differ between SGAs and AGAs at weeks 31-36. Mean IGFBP-1 was highest in the SGAs compared to AGAs at mean week 28,5 and 31 (p=.001) and IGFBP-1 levels were elevated in relation to IGF-I in the SGAs at that period. At follow-up, the increase in IGF-I between week 31 and 33.5 was a significant positive determinant of height SDS at 3 and 5 years of age in forward multiple regression analysis, independent of target height. Conclusion: This is the first study to investigate postnatal ALS levels in preterm infants. In very preterm infants, IGF-II is less affected by size at birth during early postnatal weeks compared with IGF-I. Early elevated IGFBP-1 might protect the SGA infants from an intense metabolic rate. Our results indicate that anabolic and metabolic processes during weeks 31-36 predicts later height.

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Denna text är utskriven från följande webbsida:
http://gu.se/forskning/publikation/?publicationId=293376
Utskriftsdatum: 2020-08-08