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Morphology, Volume, and Density Characteristics of the Parotid Glands before and after Chemoradiation Therapy in Patients with Head and Neck Tumors

Artikel i vetenskaplig tidskrift
Författare W. P. dos Santos
J. P. P. Gomes
A. D. Nussi
J. M. Altemani
Mtbr dos Santos
Bengt Hasséus
Daniel Giglio
P. H. Braz-Silva
A. L. F. Costa
Publicerad i International Journal of Dentistry
Volym 2020
ISSN 1687-8728
Publiceringsår 2020
Publicerad vid Institutionen för odontologi
Institutionen för kliniska vetenskaper, Avdelningen för onkologi
Språk en
Länkar dx.doi.org/10.1155/2020/8176260
Ämnesord radiation-induced xerostomia, radiotherapy, cancer, Dentistry, Oral Surgery & Medicine
Ämneskategorier Cancer och onkologi

Sammanfattning

The multimodal approach for patients with head and neck cancer (HNC) includes treatment with chemoradiation therapy (CRT). A common concern regarding CRT side effects is the occurrence of structural and physiological alterations of the salivary glands due to exposure to ionizing radiation. The aim of this study is to examine the morphology, volume, and density of the parotid glands before and after CRT in HNC patients. A total of 49 HNC patients treated exclusively with CRT were included in the study. Ninety-eight parotid glands were evaluated before and after treatment by using contrast-enhanced computed tomography (CECT). Shapiro-Wilk test was performed, and the variables (pre-CRT and post-CRT) presented normal distribution. Pearson's coefficient was used to assess the correlation between volume and density. CRT resulted in a significant decrease in the mean volume of the parotid glands (i.e., original volume reduced by 20.5%; P<0.0001). CRT induced a 30.0% (7 Hounsfield units) increase in density of the right parotid gland and a 24.9% (8 Hounsfield units) increase in density of the left parotid gland (P=0.0198 and P=0.0079, respectively). Changes in morphology and spatial configuration, increased density, and substantial loss of volume of the parotid glands were observed after CRT. There was also a difference in density (P=0.003) in the right-side parotid glands in comparison between xerostomic and nonxerostomic groups of patients. These facts lead to the need for a personalized CRT planning in order to minimize oral complications related to the treatment.

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Denna text är utskriven från följande webbsida:
http://gu.se/forskning/publikation/?publicationId=293592
Utskriftsdatum: 2020-08-09