Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Protective effect of biso… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Protective effect of bisoprolol on beta-1 adrenoceptor peptide-induced autoimmune myocardial damage in rabbits.

Artikel i vetenskaplig tidskrift
Författare S Matsui
M Persson
H M Fu
M Hayase
S Katsuda
K Teraoka
T Kurihara
Michael Fu
Publicerad i Herz
Volym 25
Nummer/häfte 3
Sidor 267-70
ISSN 0340-9937
Publiceringsår 2000
Publicerad vid Wallenberglaboratoriet
Institutionen för invärtesmedicin
Sidor 267-70
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adrenergic beta-Antagonists, pharmacology, Animals, Autoimmune Diseases, immunology, pathology, Bisoprolol, pharmacology, Cardiac Volume, drug effects, Cardiomyopathy, Dilated, immunology, pathology, Myocardium, pathology, Rabbits, Receptors, Adrenergic, beta-1, immunology
Ämneskategorier Fysiologi, Cell- och molekylärbiologi, Mikrobiologi inom det medicinska området

Sammanfattning

Idiopathic dilated cardiomyopathy is a severe disease of unknown etiology. Accumulating evidence suggests that agonist-like autoantibodies against the beta 1 adrenoceptor in the circulation of dilated cardiomyopathy may play an important role. The aim of this study was to evaluate the effects of the selective beta 1-adrenoceptor blocker, bisoprolol, on beta 1-adrenoceptor peptide induced autoimmune myocardial damage. In the animal model of autoimmune cardiomyopathy induced by active immunization of rabbits with beta 1-adrenoceptor peptide, bisoprolol was given at a dose of 3 mg/day throughout the study period. Our results showed high titer of anti-beta 1-adrenoceptor antibody in the immunized group throughout the study but not in the group receiving only bisoprolol. Cross-reactivity to beta 2 adrenoceptors was observed in some of the immunized rabbits, but disappeared almost entirely after 6 months. As compared to the beta 1-adrenoceptor peptide immunized group without bisoprolol treatment, bisoprolol treated beta 1-receptor peptide immunized group showed increase in the wall thickness and decreases in cavity dimension in anatomical measurements and only mild alterations in macro- and microscopic examinations. Thus, our study clearly demonstrated a beneficial effect of bisoprolol in rabbits who have developed autoimmune myocardial damage.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?

Denna text är utskriven från följande webbsida:
http://gu.se/forskning/publikation/?publicationId=60189
Utskriftsdatum: 2020-07-12