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Sidan uppdaterades: 2012-09-11 15:12
Författare |
Y. Borne Björn Fagerberg Gerd Sällsten B. Hedblad M. Persson O. Melander J. Nilsson M. Orho-Melander Lars Barregård G. Engstrom |
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Publicerad i | Clinical Proteomics |
Volym | 16 |
Nummer/häfte | 21 |
ISSN | 1542-6416 |
Publiceringsår | 2019 |
Publicerad vid |
Wallenberglaboratoriet Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för arbets-och miljömedicin Institutionen för medicin, avdelningen för molekylär och klinisk medicin |
Språk | en |
Länkar |
dx.doi.org/10.1186/s12014-019-9231-... |
Ämnesord | Proteomics study, Cadmium, Non-smokers, CVD, Cohort study, plasminogen-activator receptor, kidney injury molecule-1, nf-kappa-b, malmo diet, carotid plaque, cathepsin-l, exposure, mortality, cancer, risk |
Ämneskategorier | Miljömedicin |
BackgroundCadmium is a toxic metal with multiple adverse health effects, including risk of cardiovascular disease (CVD). The mechanistic link between cadmium and CVD is unclear. Our aim was to examine the associations between blood cadmium (B-Cd) and 88 potential protein biomarkers of CVD.MethodsB-Cd and 88 plasma proteins were measured in a community-based prospective cohort, the Malmo Diet and Cancer study. The primary analysis was performed in never smokers (n=1725). Multiple linear regression was used with adjustments for age and sex, and correction for multiple comparisons using the false discovery rate method. Proteins significantly associated with B-Cd were replicated in long-term former smokers (n=782). Significant proteins were then studied in relation to incidence of CVD (i.e., coronary events or ischemic stroke) in never smokers.ResultsFifteen proteins were associated with B-Cd in never smokers. Eight of them were replicated in long-term former smokers. Kidney injury molecule-1, fibroblast growth factor-23 (FGF23), tumor necrosis factor receptor-2, matrix metalloproteinase-12, cathepsin L1, urokinase plasminogen activator receptor, C-C motif chemokine-3 (CCL3), and chemokine (C-X3-C motif) ligand-1 were associated with B-Cd both in never smokers and long-term former smokers. Except for CCL3 and FGF23, these proteins were also significantly associated with incidence of CVD.ConclusionsB-Cd in non-smokers was associated with eight potential plasma biomarkers of CVD and kidney injury. The results suggest pathways for the associations between B-Cd and CVD and kidney injury.