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Association of ploidy and cell proliferation, Dukes' classification, and histopathological differentiation in adenocarcinomas of colon and rectum.

Artikel i vetenskaplig tidskrift
Författare B Wahlström
I Branehög
Ulrika Stierner
H Sunzel
Erik Holmberg
Publicerad i The European journal of surgery = Acta chirurgica
Volym 158
Nummer/häfte 4
Sidor 237-42; discussion 242-3
ISSN 1102-4151
Publiceringsår 1992
Publicerad vid Institutionen för särskilda specialiteter, Avdelningen för onkologi
Sidor 237-42; discussion 242-3
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adenocarcinoma, classification, pathology, Adult, Aged, Aged, 80 and over, Cell Division, Cell Transformation, Neoplastic, classification, pathology, Colonic Neoplasms, classification, pathology, DNA, Neoplasm, analysis, Female, Flow Cytometry, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Ploidies, Rectal Neoplasms, classification, pathology, S Phase
Ämneskategorier Cancer och onkologi

Sammanfattning

OBJECTIVES--To find out if there is an association between DNA indexes and DNA synthesis (S) phase measurements and Dukes' classification and histopathological differentiation in colorectal cancers, and to investigate the interrelationship between DNA indexes and S phase measurements. DESIGN--Prospective open study. MATERIAL--182 colorectal carcinomas in 181 consecutive patients. INTERVENTION--Tumours biopsied immediately after resection or at rectoscopy or colonoscopy. RESULTS--One or more aneuploid cell populations were found in 113 of 182 carcinomas (62%). There was no correlation between Dukes' stage and either degree of differentiation or S phase measurements, but there were significant correlations between S phase measurements and histological grading (p less than 0.05), and between the percentage of cells in the S phase and the DNA index when values for both diploid and aneuploid tumours were included (p less than 0.001). CONCLUSION--The degree of aneuploidy indicates how far tumour cells have progressed in their cellular disarrangement, and information about a tumour's proliferative capacity is given by the S phase measurements.

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