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Regional distribution of common and dysplastic naevi in relation to melanoma site and sun exposure. A case-control study.

Artikel i vetenskaplig tidskrift
Författare Ulrika Stierner
A Augustsson
Inger Rosdahl
M Suurküla
Publicerad i Melanoma research
Volym 1
Nummer/häfte 5-6
Sidor 367-75
ISSN 0960-8931
Publiceringsår 1992
Publicerad vid Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi
Institutionen för särskilda specialiteter, Avdelningen för onkologi
Sidor 367-75
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Case-Control Studies, Disease Susceptibility, Dysplastic Nevus Syndrome, epidemiology, etiology, Humans, Male, Melanocytes, pathology, radiation effects, Melanoma, epidemiology, etiology, Middle Aged, Neoplasms, Multiple Primary, epidemiology, Neoplasms, Radiation-Induced, epidemiology, Nevus, Pigmented, epidemiology, Precancerous Conditions, epidemiology, Sex Factors, Skin Neoplasms, epidemiology, etiology, Sunlight, adverse effects, Sweden, epidemiology, Ultraviolet Rays, adverse effects
Ämneskategorier Cancer och onkologi

Sammanfattning

The frequency of melanoma (CMM), and of common and dysplastic naevi (CN and DN) in areas of skin chronically, intermittently and rarely exposed to UV light was investigated in 121 melanoma patients (30-50 years) and 310 controls. Both cases and controls had significantly more CN in intermittently exposed areas than in areas chronically or rarely exposed. The ratio of observed to expected number of CMM was also highest in intermittently exposed skin (1.3 compared to 0.8 in chronically exposed and 0.5 in rarely exposed areas). Thus, intermittent UV exposure seems to have the most potent 'naevogenic' as well as carcinogenic effect on melanocytes. Nineteen per cent of controls and 56% of cases had naevi fulfilling the clinical criteria for DN. The distribution pattern of DN was clearly different from that of CN and does not accord with the idea that UV light is a major aetiological factor for DN. The probability of CMM significantly increased with the degree of relative clustering of CN (p less than 0.05) and of DN (p less than 0.01). This co-variation of naevi and CMM over the body surface might be the result of the local insults to the melanocyte system caused by UV light and/or to the fact that naevi are precursor lesions of CMM.

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