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Peripheral and intrasplenic platelet kinetics and bone marrow megakaryopoiesis in alpha-2b-interferon treated hairy cell leukemia.

Artikel i vetenskaplig tidskrift
Författare Hans Wadenvik
Inger Braide
Börje Ridell
Jack Kutti
Stefan Jacobsson
Peter Revesz
Publicerad i Leukemia research
Volym 18
Nummer/häfte 8
Sidor 569-75
ISSN 0145-2126
Publiceringsår 1994
Publicerad vid Institutionen för laboratoriemedicin , Avdelningen för patologi
Institutionen för invärtesmedicin, Avdelningen för internmedicin
Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
Sidor 569-75
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Blood Platelets, pathology, Bone Marrow, pathology, Cell Count, Cell Survival, Hematopoiesis, Humans, Interferon Alfa-2b, therapeutic use, Kinetics, Leukemia, Hairy Cell, blood, therapy, Male, Megakaryocytes, pathology, Middle Aged, Platelet Count, Spleen, pathology
Ämneskategorier Tumörbiologi, Hematologi, Klinisk kemi

Sammanfattning

In eight patients with previously untreated hairy cell leukemia (HCL), by using 111In-labelled platelets and megakaryocyte quantitation, the splenic platelet pooling and the platelet production rate (P) were evaluated before and during alpha-2b-interferon (IFN) treatment. Both before and after 8 months of IFN therapy the spleen was shown to pool a sizeable amount of the total body platelet mass. The average splenic platelet pools, prior to and after 8 months of IFN, were 58 +/- 17 and 47 +/- 11%, respectively. At the time when treatment was initiated, the patients were heterogeneous as regards the spleen size, platelet kinetics, and the bone marrow morphology. Three patients had values for P below the 95th percentile for a group of healthy control subjects; following IFN therapy they displayed a substantial increase in P. In three other HCL patients, with the largest spleens, the pre-treatment P was normal, or slightly above the values seen for the control subjects. In these patients, changes in splenic platelet pool size, blood volume, and platelet mean life-span accounted for the increase in platelet count observed in response to IFN. The mean megakaryocyte number and volume per microliter bone marrow increased during IFN therapy, while the mean P remained slightly reduced. It is concluded that splenic platelet pooling would explain the previously described difference in platelet counts between splenectomized and non-splenectomized patients treated with IFN.

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