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Intracoronary beta2 receptor activation induces dynamic local t-PA release in the pig.

Artikel i vetenskaplig tidskrift
Författare Barbro Osterlund
Christina Jern
Helene Seeman-Lodding
Göran Johansson
Sören Häggmark
Michael Broomé
Björn Biber
Publicerad i Thrombosis and haemostasis
Volym 90
Nummer/häfte 5
Sidor 796-802
ISSN 0340-6245
Publiceringsår 2003
Publicerad vid Institutionen för klinisk neurovetenskap
Sidor 796-802
Språk en
Länkar dx.doi.org/10.1267/THRO03050796
Ämnesord Adrenergic Agonists, pharmacology, Animals, Catheterization, Coronary Vessels, metabolism, physiology, Female, Fibrinolysis, Hemodynamics, drug effects, Isoproterenol, pharmacology, Kinetics, Plasminogen Activator Inhibitor 1, blood, Receptors, Adrenergic, beta-2, agonists, blood, Swine, Tissue Plasminogen Activator, blood
Ämneskategorier Medicin och Hälsovetenskap

Sammanfattning

To investigate beta2 -adrenergic agonist-mediated effects on coronary fluxes of local fibrinolytic factors, healthy anaesthetised and instrumented pigs (n=10) were studied during infusion of isoprenaline (IPR) into the left main coronary artery. Coronary net fluxes of total t-PA antigen, active t-PA and total PAI-1 antigen were determined at baseline and at 3, 5, 7 and 10 minutes of IPR infusion. During IPR, net release of total t-PA increased in a biphasic pattern with transiently high levels at 3 (+440 %) and 7 minutes (+620%) and returned towards baseline at 10 minutes. Net coronary release of active t-PA increased with maximum levels at 3 minutes (+50%). Baseline coronary net flux of total PAI -1 showed a decrease which was most pronounced at 10 minutes. To conclude, a fast beta2 agonist-mediated local release of t-PA into the coronary vasculature was demonstrated. For total t-PA, this response was characterised by a biphasic release profile.

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