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Induction of a pharmacologically active clonotypic B cell response directed to an immunogenic region of the human beta 2-adrenergic receptor.

Artikel i vetenskaplig tidskrift
Författare J G Guillet
R Lengagne
Yvonne Magnusson
K Tate
A D Strosberg
Johan Hoebeke
Publicerad i Clinical and experimental immunology
Volym 89
Nummer/häfte 3
Sidor 461-7
ISSN 0009-9104
Publiceringsår 1992
Publicerad vid Wallenberglaboratoriet
Sidor 461-7
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Animals, Antibodies, Monoclonal, B-Lymphocytes, ultrastructure, Clone Cells, Epitopes, Mice, Mice, Inbred A, Mice, Inbred BALB C, Mice, Inbred C57BL, Receptors, Adrenergic, beta, immunology
Ämneskategorier Mikrobiologi inom det medicinska området

Sammanfattning

It has been reported that autoantibodies against the beta 2-adrenergic receptors are involved in the pathology of allergic disorders and of Chagas' disease. Therefore, the immune response against a peptide (H26Q) corresponding to the putative second extracellular loop of the human beta 2-adrenergic receptor, which could be a target for autoantibody attack, was analysed in view of its possible immunogenicity. The free peptide induced a T cell-mediated humoral response in the context of three different murine MHC haplotypes. The T cell epitope was found to be localized in the N-terminal region of the peptide. Highly specific T helper cells were capable of stimulating B cells with the potential to generate a large antibody repertoire reactive with the loop peptide. MoAbs were screened to analyse this B cell response for antibodies potentially interfering with receptor function and a MoAb was found that impaired ligand binding to the receptor.

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