Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Allele-specific regulatio… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease.

Artikel i vetenskaplig tidskrift
Författare A Aminoff
H Ledmyr
P Thulin
K Lundell
Leyla Nunez
Elisabeth Strandhagen
C Murphy
Ulf Lidberg
Jukka Westerbacka
A Franco-Cereceda
J Liska
LB Nielsen
M Gåfvels
M Nastase Mannila
Anders Hamsten
Hannele Yki-Järvinen
Dag Thelle
Per Eriksson
Jan Borén
E Ehrenborg
Publicerad i Journal of lipid research
Volym 51
Nummer/häfte 1
Sidor 103-11
ISSN 0022-2275
Publiceringsår 2010
Publicerad vid Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för medicin, avdelningen för molekylär och klinisk medicin
Sidor 103-11
Språk en
Länkar dx.doi.org/10.1194/jlr.M900195-JLR2...
Ämnesord Aged, Alleles, Base Sequence, CCAAT-Enhancer-Binding Proteins, genetics, metabolism, Carrier Proteins, genetics, Case-Control Studies, Fatty Liver, genetics, metabolism, Female, Gene Expression Regulation, Heart, physiology, Hela Cells, Humans, Liver, metabolism, Macrophages, metabolism, Male, Middle Aged, Monocytes, metabolism, Myocardial Ischemia, genetics, Polymorphism, Single Nucleotide, Promoter Regions, Genetic, Response Elements, genetics
Ämneskategorier Kardiovaskulär medicin

Sammanfattning

Promoter polymorphisms in microsomal triglyceride transfer protein (MTTP) have been associated with decreased plasma lipids but an increased risk for ischemic heart disease (IHD), indicating that MTTP influences the susceptibility for IHD independent of plasma lipids. The objective of this study was to characterize the functional promoter polymorphism in MTTP predisposing to IHD and its underlying mechanism. Use of pyrosequencing technology revealed that presence of the minor alleles of the promoter polymorphisms -493G>T and -164T>C result in lower transcription of MTTP in vivo in the heart, liver, and macrophages. In vitro experiments indicated that the minor -164C allele mediates the lower gene expression and that C/EBP binds to the polymorphic region in an allele-specific manner. Furthermore, homozygous carriers of the -164C were found to have increased risk for IHD as shown in a case-control study including a total of 544 IHD patients and 544 healthy control subjects. We concluded that carriers of the minor -164C allele have lower expression of MTTP in the heart, mediated at least partly by the transcription factor CCAAT/enhancer binding protein, and that reduced concentration of MTTP in the myocardium may contribute to IHD upon ischemic damage.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?