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Clinical and experimental studies of octocrylene's allergenic potency

Artikel i vetenskaplig tidskrift
Författare Isabella Karlsson
Katrien Vanden Broecke
Jerker Mårtensson
An Goossens
Anna Börje
Publicerad i Contact Dermatitis
Volym 64
Nummer/häfte 6
Sidor 343-52
ISSN 1600-0536
Publiceringsår 2011
Publicerad vid Institutionen för kemi
Sidor 343-52
Språk en
Länkar dx.doi.org/10.1111/j.1600-0536.2011...
Ämneskategorier Kemi

Sammanfattning

Background. Reports of positive patch test and photopatch test reactions to the chemical ultraviolet filter octocrylene have increased during the last decade. Little is known about the reason for octocrylene's allergenic activity. Objectives. To present and discuss the results of patch tests and photopatch tests with octocrylene, and to investigate the possible cause of its allergenic properties. Methods. Results of patch tests and photopatch tests with octocrylene in patients with adverse skin reactions to sunscreen products and/or ketoprofen were collected. The allergenic potency of octocrylene was investigated in the murine local lymph node assay (LLNA). Chemical reactivity assays were used to mimic octocrylene's interaction with biomolecules. Results. We report 23 cases of positive test reactions to octocrylene (5 patch test and 18 photopatch). Notably, many of these patients also had positive photopatch test reactions to ketoprofen and benzophenone-3. Octocrylene was shown to be a moderate sensitizer in the LLNA, and it reacted with amines such as lysine, but not with thiols such as cysteine. Conclusions. The clinical studies show that octocrylene is both a photocontact allergen and a contact allergen. Octocrylene's ability to cause contact allergy is probably attributable to its reactivity towards lysine. To be able to understand why octocrylene causes photocontact allergy, further studies are needed.

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