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Urinary excretion of 5-S-cysteinyldopa in relation to skin type, UVB-induced erythema, and melanocyte proliferation in human skin.

Artikel i vetenskaplig tidskrift
Författare Ulrika Stierner
Inger Rosdahl
A Augustsson
B Kågedal
Publicerad i The Journal of investigative dermatology
Volym 91
Nummer/häfte 5
Sidor 506-10
ISSN 0022-202X
Publiceringsår 1988
Publicerad vid Medicinska institutionen
Sidor 506-10
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adult, Cell Division, radiation effects, Cysteinyldopa, urine, Dihydroxyphenylalanine, analogs & derivatives, Epidermis, cytology, radiation effects, Erythema, etiology, pathology, urine, Female, Humans, Male, Melanocytes, cytology, radiation effects, Middle Aged, Skin, cytology, radiation effects, Tumor Markers, Biological, urine, Ultraviolet Rays, adverse effects
Ämneskategorier Cancer och onkologi

Sammanfattning

5-S-Cysteinyldopa (5-S-CD) is found in all pigment-producing cells and is the major precursor of phaeomelanin. However, the melanocyte specificity of the compound has been questioned. In order to elucidate the origin of 5-S-CD, we have now systematically studied the relationship between the 5-S-CD excretion in urine and the size of the melanocyte organ, UV-induced melanocyte proliferation, skin type, and the erythemal reaction. The skin type had no influence on the basal excretion of 5-S-CD. There was no significant correlation between the basal 5-S-CD excretion and the size of the melanocyte organ; that is, the number of skin melanocytes and nevi. During the irradiation, subjects with skin type II developed a more pronounced erythema (p less than 0.01) and had a significantly higher 5-S-CD excretion than those with skin type III-IV (p less than 0.01). No correlation was found between 5-S-CD excretion and UV-induced melanocyte proliferation. The lack of correlation between the basal 5-S-CD excretion and skin type or number of melanocytes suggests that the basal 5-S-CD in urine is mainly of extra-melanocytic origin. Our findings favor the view that the increase in 5-S-CD excretion during UV irradiation is due to UV damage.

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