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No evidence for an association between ABO blood group and overall ischemic stroke or any of the major etiologic subtypes

Artikel i vetenskaplig tidskrift
Författare Ellen Hanson
Sara Karlsson
Katarina Jood
Staffan Nilsson
Christian Blomstrand
Christina Jern
Publicerad i Thrombosis Research
Volym 130
Nummer/häfte 3
Sidor 339-342
ISSN 0049-3848
Publiceringsår 2012
Publicerad vid Institutionen för neurovetenskap och fysiologi
Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering
Institutionen för matematiska vetenskaper, matematisk statistik
Sidor 339-342
Språk en
Länkar dx.doi.org/10.1016/j.thromres.2012....
https://gup.ub.gu.se/file/192098
Ämnesord ABO blood group, Ischemic stroke, TOAST subtype, cerebral-hemorrhage, risk, disease, infarction, genotype
Ämneskategorier Neurologi

Sammanfattning

Introduction: The ABO blood group system is encoded by one gene, ABO. Previous studies have reported an association between blood group non-O (i.e. phenotype A, B or AB) and myocardial infarction. Studies on stroke and ABO are, however, more scarce. Therefore, we aimed to investigate whether ABO phenotype or genotype is associated with ischemic stroke and/or etiologic subtypes of ischemic stroke. Materials and methods: The study was performed in the Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS), which comprises 600 patients with ischemic stroke before the age of 70 years, and 600 matched controls. Patients were classified according to the TOAST criteria. Results: There was no significant association between ABO phenotype (blood group O vs. non-O) and overall ischemic stroke (multivariable odds ratio of 0.9, 95% confidence interval 0.7-1.2). This was also true for blood group O vs. A and O vs. B. Furthermore, no association between ABO genotypes and ischemic stroke was detected. The ischemic stroke subtype analysis was confined to large-vessel disease, small-vessel disease, cardioembolic stroke and cryptogenic stroke. In this analysis, there was no significant association between any ischemic stroke subtype and ABO phenotype or genotype. Conclusions: The findings in this study suggest that ABO phenotype or genotype does not have a major impact in the pathophysiology of ischemic stroke or any of the ischemic stroke subtypes.

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