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The first European interdisciplinary ewing sarcoma research summit.

Artikel i vetenskaplig tidskrift
Författare Heinrich Kovar
Javier Alonso
Pierre Åman
Dave N T Aryee
Jozef Ban
Sue A Burchill
Stefan Burdach
Enrique De Alava
Olivier Delattre
Uta Dirksen
Argyro Fourtouna
Simone Fulda
Lee J Helman
David Herrero-Martin
Pancras C W Hogendoorn
Udo Kontny
Elizabeth R Lawlor
Stephen L Lessnick
Antonio Llombart-Bosch
Markus Metzler
Richard Moriggl
Stephan Niedan
Jenny Potratz
Françoise Redini
Günther H S Richter
Lucia T Riedmann
Claudia Rossig
Beat W Schäfer
Raphaela Schwentner
Katia Scotlandi
Poul H Sorensen
Martin S Staege
Franck Tirode
Jeffrey Toretsky
Selena Ventura
Angelika Eggert
Ruth Ladenstein
Publicerad i Frontiers in oncology
Volym 2
Sidor 54
ISSN 2234-943X
Publiceringsår 2012
Publicerad vid Institutionen för biomedicin, avdelningen för patologi
Sidor 54
Språk en
Länkar dx.doi.org/10.3389/fonc.2012.00054
Ämneskategorier Medicinska grundvetenskaper

Sammanfattning

The European Network for Cancer Research in Children and Adolescents (ENCCA) provides an interaction platform for stakeholders in research and care of children with cancer. Among ENCCA objectives is the establishment of biology-based prioritization mechanisms for the selection of innovative targets, drugs, and prognostic markers for validation in clinical trials. Specifically for sarcomas, there is a burning need for novel treatment options, since current chemotherapeutic treatment protocols have met their limits. This is most obvious for metastatic Ewing sarcoma (ES), where long term survival rates are still below 20%. Despite significant progress in our understanding of ES biology, clinical translation of promising laboratory results has not yet taken place due to fragmentation of research and lack of an institutionalized discussion forum. To fill this gap, ENCCA assembled 30 European expert scientists and five North American opinion leaders in December 2011 to exchange thoughts and discuss the state of the art in ES research and latest results from the bench, and to propose biological studies and novel promising therapeutics for the upcoming European EWING2008 and EWING2012 clinical trials.

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