Till sidans topp

Sidansvarig: Webbredaktion
Sidan uppdaterades: 2012-09-11 15:12

Tipsa en vän
Utskriftsversion

Autologous chondrocyte tr… - Göteborgs universitet Till startsida
Webbkarta
Till innehåll Läs mer om hur kakor används på gu.se

Autologous chondrocyte transplantation. Biomechanics and long-term durability.

Artikel i vetenskaplig tidskrift
Författare Lars Peterson
Mats Brittberg
Illka Kiviranta
Evy Lundgren Akerlund
Anders Lindahl
Publicerad i The American journal of sports medicine
Volym 30
Nummer/häfte 1
Sidor 2-12
ISSN 0363-5465
Publiceringsår 2002
Publicerad vid Institutionen för de kirurgiska disciplinerna, Avdelningen för ortopedi
Institutionen för laboratoriemedicin, Avdelningen för klinisk kemi/transfusionsmedicin
Sidor 2-12
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adolescent, Adult, Anterior Cruciate Ligament, surgery, Arthroscopy, Biomechanics, Biopsy, Cartilage, Articular, injuries, pathology, physiopathology, surgery, Chondrocytes, transplantation, Female, Femur, injuries, Follow-Up Studies, Graft Survival, physiology, Humans, Knee Injuries, pathology, physiopathology, surgery, Male, Middle Aged, Osteochondritis Dissecans, surgery, Patella, injuries, Second-Look Surgery, Statistics as Topic, Transplantation, Autologous, methods, Treatment Outcome
Ämneskategorier Ortopedi, Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Sammanfattning

We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of normal cartilage in eight patients. Eight of twelve 2-mm biopsy samples taken from these patients showed hyaline characteristics with safranin O staining and a homogeneous appearance in polarized light. Three fibrous and eight hyaline biopsy specimens stained positive to aggrecan and to cartilage oligomeric matrix protein. Hyaline-like specimens stained positive for type II collagen, and fibrous, for type I collagen. Autologous chondrocyte transplantation for the treatment of articular cartilage injuries has a durable outcome for as long as 11 years.

Sidansvarig: Webbredaktion|Sidan uppdaterades: 2012-09-11
Dela:

På Göteborgs universitet använder vi kakor (cookies) för att webbplatsen ska fungera på ett bra sätt för dig. Genom att surfa vidare godkänner du att vi använder kakor.  Vad är kakor?