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Mercury in serum predicts low risk of death and myocardial infarction in Gothenburg women.

Artikel i vetenskaplig tidskrift
Författare Ingvar A Bergdahl
Margareta Ahlqwist
Lars Barregård
Cecilia Björkelund
Ann Blomstrand
Staffan Skerfving
Valter Sundh
Maria Wennberg
Lauren Lissner
Publicerad i International archives of occupational and environmental health
Volym 86
Nummer/häfte 1
Sidor 71-7
ISSN 1432-1246
Publiceringsår 2013
Publicerad vid Institutionen för odontologi
Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
Institutionen för medicin
Sidor 71-7
Språk en
Länkar dx.doi.org/10.1007/s00420-012-0746-...
https://gup.ub.gu.se/file/97127
Ämnesord Mercury, Fish, Amalgam, Mortality, Cardiovascular, Myocardial infarction, Stroke
Ämneskategorier Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Annan medicin och hälsovetenskap

Sammanfattning

Abstract Purpose Markers of mercury (Hg) exposure have shown both positive and negative associations with cardiovascular disease (CVD). We assessed the association between serum Hg (S–Hg) and risk of cardiovascular disease in a prospective population-based cohort, with attention to the roles of dental health and Wsh consumption. Methods Total mortality, as well as morbidity and mortality from acute myocardial infarction (AMI) and stroke, was followed up for 32 years in 1,391 women (initially age 38–60), in relation to S–Hg at baseline, using Cox regression models. Potential confounders (age, socioeconomic status, serum lipids, alcohol consumption, dental health, smoking, hypertension, waist-hip ratio, and diabetes) and other covariates (e.g., Wsh consumption) were also considered. Results Hazard ratios (HR) adjusted only for age showed strong inverse associations between baseline S–Hg and total mortality [highest quartile: hazard ratio (HR) 0.76; 95% conWdence interval (CI) 0.59–0.97], incident AMI (HR 0.56; CI 0.34–0.93), and fatal AMI (HR 0.31; CI 0.15–0.66). Adjustment for potential confounding factors, especially dental health, had a strong impact on the risk estimates, and after adjustment, only the reduced risk of fatal AMI remained statistically signiWcant. Conclusions There was a strong inverse association between Hg exposure and CVD. Likely, reasons are confounding with good dental health (also correlated with the number of amalgam Wllings in these age groups) and/or Wsh consumption. The results suggest potential eVects of dental health and/or Wsh consumption on CVD that deserve attention in preventive medicine.

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