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Increased adherence of Staphylococcus aureus from cystic fibrosis lungs to airway epithelial cells.

Artikel i vetenskaplig tidskrift
Författare U E Schwab
Agnes E Wold
J L Carson
M W Leigh
P W Cheng
P H Gilligan
T F Boat
Publicerad i The American review of respiratory disease
Volym 148
Nummer/häfte 2
Sidor 365-9
ISSN 0003-0805
Publiceringsår 1993
Publicerad vid Institutionen för laboratoriemedicin, Avdelningen för klinisk immunologi
Sidor 365-9
Språk en
Länkar www.ncbi.nlm.nih.gov/entrez/query.f...
Ämnesord Adolescent, Adult, Bacterial Adhesion, drug effects, Bronchi, microbiology, pathology, Bronchoalveolar Lavage Fluid, microbiology, Cell Line, Child, Child, Preschool, Cystic Fibrosis, genetics, microbiology, pathology, Endopeptidase K, Epithelium, microbiology, pathology, Female, Humans, Male, Middle Aged, Mouth Mucosa, pathology, Nasal Mucosa, pathology, Serine Endopeptidases, pharmacology, Sputum, microbiology, Staphylococcus aureus, drug effects, physiology, Trachea, microbiology, Trypsin, pharmacology
Ämneskategorier Lungmedicin och allergi, Infektionsmedicin, Mikrobiologi inom det medicinska området

Sammanfattning

Airway colonization by Staphylococcus aureus is a frequent feature of cystic fibrosis (CF). To assess the pathogenesis of selective colonization with this organism, we compared the capacity of S. aureus isolated from the respiratory tract of CF and non-CF patients to adhere to epithelial cells from the upper and lower airways of CF and control subjects. Bacterial adherence to bronchial epithelial cell lines was significantly greater for CF than for non-CF isolates (p < 0.001). Of 17 CF S. aureus isolates 12 adhered at a level > 1 bacterium per cell; this was true for only 1 of 14 non-CF isolates. CF S. aureus isolates also bound more avidly than non-CF isolates to ciliated (p < 0.05) and squamous nasal cells (p < 0.02) and buccal epithelial cells (p < 0.005) freshly harvested by scraping. Each S. aureus isolate bound with equal avidity to epithelial cells from CF patients and healthy individuals. Adherence was not related to sex, age, severity of pulmonary disease, presence of other microorganisms in the airways, or genotype of the CF hosts. Binding of S. aureus was blocked by proteinase treatment of organisms, suggesting that adherence is mediated by one or more peptide adhesins. We propose that the high prevalence of adherent S. aureus is due either to selection of adherent strains by CF airways or to induction of an adherent phenotype by factors residing at the CF airways surface.

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